The new species Draba heilii from the alpine tundra of northern New Mexico, and D. mulliganii from limestone and serpentine outcrops in Alaska, are described. From the related D. standleyi, D. heilii is distinguished by the smaller leaves undifferentiated (vs. strongly differentiated) into blade and petiole, thickened midvein (vs. not thickened), setose (vs. non-setose) leaf margin, and lanceolate (vs. linear-elliptic to elliptic) fruits. Draba mulliganii differs from the related D. porsildii by the broadly obovate petals 3.2–4.0 mm long (vs. spatulate petals 1.5–2.2 mm long), non-appressed fruits with styles 0.4–1.0 mm long (vs. appressed fruits with styles 0.05–0.10 mm long), and abaxial leaf surface with 8–12-rayed stellate trichomes often without spurred rays (vs. 3–5-rayed trichomes often with some rays 1-spurred).