A new species of Ficus sect. Pharmacosycea, endemic to the municipality of Barbacoa, Nariño, Colombia is here described and illustrated as Ficus dewolfii Pederneiras & Romaniuc. It is characterized by a caudate leaf apex and lateral veins diverging from the midrib almost at a right angle, and shows similarities with F. rieberiana, F. apollinaris, and F. mutisii.