Senecio pseudodepressus, a new species from the Province of San Juan, Argentina, is described and illustrated. Senecio pseudodepressus is morphologically similar to Senecio depressus, but it is distinguished by having mostly 3–8-dentate leaves, pedunculate capitula and pubescent achenes. The new species is assigned to Senecio section Senecio series Chilenses subseries Candidi by its subshrubby habit, tomentose indumentum and solitary discoid capitula. A key to distinguish species of Senecio subser. Candidi with dentate leaves and large involucres is provided. The differences between Senecio pseudodepressus and its related taxa are also discussed.