Two new Salvia species from Durango are described and illustrated. These were revealed while preparing a preliminary list of Salvia for this Mexican state. Salvia durangensis is characterized by ovate leaves, subcordate at the base, deciduous floral bracts, calyx less than 8 mm long, 3-veined upper calyx lip, red corollas without white nectar guides, corolla tube less than 21 mm long, shortly deflexed lower corolla lip, included stamens, glabrous style, and acute lower stigmatic branch. Whereas, Salvia odam can be distinguished by its oblong-lanceolate to ovate leaves with white abaxial surface, deciduous floral bract, yellowish-green calyces, 3 (or sub-5) veined upper calyx lip, white upper corolla tube and lip, dark blue lower corolla lip with white nectar guides, included stamens, pilose style, and acute lower stigmatic branch. Both species are compared with other morphologically similar species and an identification key to native Salvia species of Durango is provided.