This study investigated biological activity of chloroform extract of dry Lantana camara ‘Mozelle’ leaves against the eastern subterranean termite, Reticulitermes flavipes (Kollar), an important structural pest. Repellent activity was assessed using a paper-disc choice test and a sand arena choice test. Antifeedant and toxic properties were assessed using a no-choice paper test and a topical application method. In the choice tests, significantly fewer termites made contact with treated paper-discs at test concentrations ≥0.016 mg/cm² (equivalent to 0.0023 wt:wt) or tunneled into treated sand at test concentrations ≥0.125 mg/g, compared with control. In the no-choice tests, termite feeding activity was significantly reduced and termite mortality was greatly increased in treatments than control. Exposure to filter paper treated at 0.212 and 0.106 mg/cm² (equivalent to 0.03 and 0.015 wt:wt) resulted in >90% mortality and 78% reduction in feeding, and ≈52% mortality and 40% reduction in feeding, respectively. Top-dorsal application led to >60% mortality at 4 µg/termite. This study showed that the chloroform leaf extract of L. camara had excellent repellent and moderate toxic and antifeedant activities.