In this study, we investigated the effects of environmental factors (temperature, dose, dietary source, and feeding density) on the insecticide tolerance of Bactrocera dorsalis (Hendel) (Diptera: Tephritidae). The results indicated that the toxicities of trichlorphon and abamectin to B. dorsalis increased with an increase in temperature. At 15–35°C, the toxicity of β-cypermethrin decreased with an increase in temperature at low doses (0.82 and 1.86 mg/L), but was similar at a high dose (4.18 mg/L). These results demonstrated that the temperature coefficient of β-cypermethrin was related to both temperature and dosage. The insecticide sensitivity of B. dorsalis reared on different dietary sources was significantly different. Trichlorphon sensitivity of B. dorsalis fed on banana was the highest with an LC₅₀ of 1.61 mg/L, followed by on apple, carambola, semiartificial diet, pear, mango, guava, orange, and papaya. With an increasing feeding density, the sensitivity of B. dorsalis adults to trichlorphon increased, while the sensitivities of B. dorsalis adults to abamectin and β-cypermethrin decreased. The differences between LC₅₀ values of insects reared at densities of 10 and 13 eggs/g of semiartificial diet to trichlorphon, abamectin and β-cypermethrin were not significant. This result suggested that representative toxicity could be obtained by using adults developed at a feeding density between 10–13 eggs/g of semiartificial diet. Adult body weight was positively correlated with the LC₅₀ value of trichlorphon, but was negatively correlated with the toxicities of abamectin and β-cypermethrin. These results suggested that the effects of adult body weight on the toxicity of insecticides were different among different chemicals.