Coyotes (Canis latrans) pose a risk to domestic cats (Felis catus). We captured, radiocollared, and tracked 8 coyotes from November 2005 to February 2006 for 790 hours in Tucson, Arizona, USA. We observed 36 coyote–cat interactions; 19 resulted in coyotes killing cats. Most cats were killed in residential areas from 2200 hours to 0500 hours during the pup-rearing season. Single coyotes were as effective killing cats as were groups (>1) of coyotes. Documented cases of predators killing cats could encourage cat owners to keep their cats indoors and assist wildlife managers in addressing urban wildlife issues.