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1 October 2001 UV Erythema Reducing Capacity of Mizolastine Compared to Acetyl-salicylic Acid or both Combined in Comparison to Indomethacin 
Jens-Uwe Grundmann, Raik Böckelmann, Bernd Bonnekoh, Harald P. M. Gollnick
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Abstract

UV light exerts hazardous effects such as induction of skin cancer and premature skin aging. In this study we evaluated an assumptive anti-inflammatory effect of the nonsedative histamine H1-receptor antagonist, mizolastine, on UV-induced acute sunburn reaction. Therefore, a clinical, randomized, double-blind, four-arm, crossover study was conducted in healthy young female volunteers (skin type II) comparing the UV sensitivity under mizolastine, acetyl-salicylic acid (ASA), indomethacin or a mizolastine/ASA combination. Moreover, HaCaT keratinocytes were incubated with mizolastine under various UV treatment modalities in vitro to study its effect on the release of inflammatory cytokines, i.e. interleukin (IL)-1α, IL-6 and tumor necrosis factor α (TNF-α). All three drugs were effective in suppressing the UVB-, UVA- and combined UVA/UVB-erythema. However, the strongest effects were observed using the combined treatment with both 250 mg ASA and 10 mg mizolastine. An inhibitory effect in vitro of 10 nM mizolastine upon UV-induced cytokine release from HaCaT keratinocytes was observed for IL-1α at 24 h after 10 J/cm2 UVA1, for IL-6 at 48 h after 10 J/cm2 UVA1 and 30 mJ/cm2 UVB, and also for TNF-α at 4 h after 10 J/cm2 UVA, 10 J/cm2 UVA1 and 30 mJ/cm2 UVB, respectively. The combination of mizolastine and ASA can be strongly recommended as a protective measure against UV erythema development with a lower unwanted side effect profile than that of the hitherto treatment modality, i.e. indomethacin.

Jens-Uwe Grundmann, Raik Böckelmann, Bernd Bonnekoh, and Harald P. M. Gollnick "UV Erythema Reducing Capacity of Mizolastine Compared to Acetyl-salicylic Acid or both Combined in Comparison to Indomethacin ," Photochemistry and Photobiology 74(4), 587-592, (1 October 2001). https://doi.org/10.1562/0031-8655(2001)074<0587:UERCOM>2.0.CO;2
Received: 25 January 2001; Accepted: 1 July 2001; Published: 1 October 2001
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