Sera derived from skunks, raccoons, opossums and woodchucks trapped in Maryland were examined for neutralizing antibodies to infectious canine hepatitis, canine distemper, canine herpes, and parainfluenza SV-5 viruses. Neutralizing antibodies to infectious canine hepatitis, previously found in skunks in the area, were demonstrated in 6 of 50 raccoons. Sera from 2 of 25 skunks and 21 of 25 raccoons had canine distemper neutralizing antibodies. Infectious canine hepatitis and canine distemper antibodies were not demonstrable in sera of 25 opossums and 9 woodchucks. No neutralizing antibody to canine herpes or SV-5 virus were found in any of the sera tested.