The present study evaluated the effects of fluoxetine on decreasing stereotypic behaviors in Asiatic black bears (ABB). Four captive ABB exhibiting stereotypic behaviors were administered fluoxetine (0.25–1 mg/ kg orally every 24 hr) for 91 days. The animals were monitored twice weekly for 213 days (April to October) using a scan sampling method (preadministration, 30 day; administration, 91 days; postadministration, 92 days). Five blood samples were collected from the jugular vein of each bear for serum chemistry analysis (one during preadministration; two each during administration and postadministration periods). Fluoxetine was safe and effective in decreasing stereotypies, but it may be difficult to decrease long-established stereotypies in ABB using fluoxetine alone. To decrease stereotypies in ABB effectively, it is necessary to identify underlying problems that contribute to stereotypic behavior and apply comprehensive interventions that can include fluoxetine treatment.