Based on the study of type and exhaustive non-type material from many entomological collections, six species of the Afrotropical genus Pyrgotomyia, viz. P. callosa sp. n. (Cameroon), P. terebrans sp. n. (Ivory Coast), P. stuckenbergi sp. n. (Nigeria), P. ciliata Hendel, 1934, P. richteri (Steyskal, 1972) comb. n., and P. temporalis (Enderlein, 1942) comb. n., are described or redescribed, illustrated and keyed. Metropina Enderlein, 1942 (type species Metropina temporalis Enderlein, 1942) is shown to be a junior synonym of Pyrgotomyia Hendel, 1934 (type species Pyrgotomyia ciliata Hendel, 1934). The possibility that P. ciliata, based on a single male holotype specimen, could be a senior synonym of either P. richteri or P. temporalis, each based on female specimens alone, is discussed.