Based on the newly acquired and previously published data the diversity patterns of Stizopina (Tenebrionidae: Tenebrioninae: Opatrini) are analyzed. At present, the subtribe consists of 101 species and subspecies (in 22 genera) distributed in the arid ecosystems of southern Africa and Madagascar. The highest diversity of species was reported from the Succulent Karoo ecoregion (near the Namibia-South Africa border). Vector data model for Endrödy-Younga's Coleoptera zones is provided. A new genus, Eichleria, with two new species (E. davidi, E. ostrowskii) of the subtribe Stizopina is described from the Nama Karoo ecoregion (Republic of South Africa). Eichleria differs from the related genera Amathobius and Nemanes in having mentum with median carina, convex pronotum, narrow intercoxal process of prosternum, fine pronotal and elytral sculpture, obtuse protibiae, and straight male mesotibiae.