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1 October 2003 Immunization of Turkeys with a DNA Vaccine Expressing Either the F or N Gene of Avian Metapneumovirus
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Abstract

SUMMARY. In this study we compared protection by DNA vaccination with the F (pCMV-F) or N (pCMV-N) gene from avian metapneumovirus (aMPV) in turkeys. One-week-old turkey poults received two intramuscular injections 2 wk apart. Birds were challenged with a turkey-embryo-adapted aMPV at 5 wk of age. Birds vaccinated with pCMV-F had decreased clinical signs of disease as well as significantly reduced virus load in tracheal swabs compared with birds vaccinated with pCMV-N or unvaccinated control birds. Serum neutralizing antibodies were significantly higher in birds receiving pCMV-F compared with all other groups. These results indicate that DNA vaccination with the F, but not N, gene of aMPV can induce significant protection against aMPV infection.

Darrell R. Kapczynski and Holly S. Sellers "Immunization of Turkeys with a DNA Vaccine Expressing Either the F or N Gene of Avian Metapneumovirus," Avian Diseases 47(4), 1376-1383, (1 October 2003). https://doi.org/10.1637/7033
Received: 13 February 2003; Published: 1 October 2003
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