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1 September 2003 Mechanisms of Pathogenicity of Influenza A (H5N1) Viruses in Mice
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Abstract

Avian-like H5N1 influenza viruses isolated from humans in 1997 were shown to have two distinct pathogenic phenotypes in BALB/c mice, after intranasal inoculation and without prior adaptation to this host. To further understand the mechanisms of H5N1 pathogenicity, we investigated the consequences of the route of viral inoculation on morbidity and mortality, viral replication in pulmonary and systemic organs, and lymphocyte depletion. This study demonstrates the importance of extrapulmonary spread and replication, particularly in the brain, for the lethality of H5N1 viruses.

R. A. Bright, D. S. Cho, T. Rowe, and J. M. Katz "Mechanisms of Pathogenicity of Influenza A (H5N1) Viruses in Mice," Avian Diseases 47(s3), 1131-1134, (1 September 2003). https://doi.org/10.1637/0005-2086-47.s3.1131
Received: 14 April 2002; Published: 1 September 2003
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