Translator Disclaimer
1 September 2003 Strategies to Improve Protection Against Low-Pathogenicity H7 Avian Influenza Virus Infection Using DNA Vaccines
Author Affiliations +
Abstract
Eukaryotic expression plasmids encoding either the avian influenza hemagglutinin or matrix genes (pCMV-HA and pCMV-M, respectively) were constructed. The viral genes were derived from a low-pathogenicity H7N1 strain, A/Chicken/Italy/1067/99, isolated during the 1999–2001 epizootic in Italy. The plasmid was administered to 4-to-5-wk-old specific-pathogen-free chickens by several different injection methods. For the initial studies comparing methods of vaccine injection, results were compared based on hemagglutination inhibition (HI) response following immunization with pCMV-HA. Additional studies with coadministration of both pCMV-HA and pCMV-M was evaluated based on HI response and viral isolation after homologous challenge. Preliminary results indicate that a device intended to inject insulin in humans (Medijector) and the coadministration of both plasmids improved protection against H7 infection.
M. Cherbonnel, J. Rousset and V. Jestin "Strategies to Improve Protection Against Low-Pathogenicity H7 Avian Influenza Virus Infection Using DNA Vaccines," Avian Diseases 47(s3), (1 September 2003). https://doi.org/10.1637/0005-2086-47.s3.1181
Received: 14 April 2002; Accepted: ; Published: 1 September 2003
JOURNAL ARTICLE
6 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top