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1 March 2008 Mucosal Vaccination with Formalin-Inactivated Avian Metapneumovirus Subtype C Does Not Protect Turkeys Following Intranasal Challenge
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Abstract

Studies were performed to determine if mucosal vaccination with inactivated avian metapneumovirus (aMPV) subtype C protected turkey poults from clinical disease and virus replication following mucosal challenge. Decreases in clinical disease were not observed in vaccinated groups, and the vaccine failed to inhibit virus replication in the tracheas of 96% of vaccinated birds. Histopathologically, enhancement of pulmonary lesions following virus challenge was associated with birds receiving the inactivated aMPV vaccine compared to unvaccinated birds. As determined by an enzyme-linked immunosorbent assay (ELISA), all virus-challenged groups increased serum immunoglobulin (Ig) G and IgA antibody production against the virus following challenge; however, the unvaccinated aMPV-challenged group displayed the highest increases in virus-neutralizing antibody. On the basis of these results it is concluded that intranasal vaccination with inactivated aMPV does not induce protective immunity, reduce virus shedding, or result in decreased histopathologic lesions.

Darrell R. Kapczynski, Laura L. Perkins, and Holly S. Sellers "Mucosal Vaccination with Formalin-Inactivated Avian Metapneumovirus Subtype C Does Not Protect Turkeys Following Intranasal Challenge," Avian Diseases 52(1), 28-33, (1 March 2008). https://doi.org/10.1637/7821-122706-Reg
Received: 27 December 2006; Accepted: 1 September 2007; Published: 1 March 2008
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