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1 September 2008 Using Mean Infectious Dose of High- and Low-Pathogenicity Avian Influenza Viruses Originating from Wild Duck and Poultry as One Measure of Infectivity and Adaptation to Poultry
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Abstract

The mean infectious doses of selected avian influenza virus (AIV) isolates, determined in domestic poultry under experimental conditions, were shown to be both host-dependent and virus strain–dependent and could be considered one measure of the infectivity and adaptation to a specific host. As such, the mean infectious dose could serve as a quantitative predictor for which strains of AIV, given the right conditions, would be more likely transmitted to and maintained in a given species or subsequently cause an AI outbreak in the given species. The intranasal (IN) mean bird infectious doses (BID50) were determined for 11 high-pathogenicity AIV (HPAIV) isolates of turkey and chicken origin for white leghorn (WL) chickens, and for low-pathogenicity AIV (LPAIV) isolates of chicken (n  =  1) and wild mallards (n  =  2) for turkeys, and WL and white Plymouth rock (WPR) chickens, domestic ducks and geese, and Japanese quail. The BID50 for HPAIV isolates for WL chickens ranged from 101.2 to 104.7 mean embryo infectious dose (EID50) (median  =  102.9). For chicken-origin HPAIV isolates, the BID50 in WL chickens ranged from 101.2 to 103.0 EID50 (median  =  102.6), whereas for HPAIV isolates of turkey origin, the BID50 in WL chickens was higher, ranging from 102.8 to 104.7 EID50 (median  =  103.9). The BID50 of 104.7 was for a turkey-origin HPAIV virus that was not transmitted to chickens on the same farm, suggesting that, under the specific conditions present on that farm, there was insufficient infectivity, adaptation, or exposure to that virus population for sustained chicken transmission. Although the upper BID50 limit for predicting infectivity and sustainable transmissibility for a specific species is unknown, a BID50 < 104.7 was suggestive of such transmissibility. For the LPAIVs, there was a trend for domestic ducks and geese and Japanese quail to have the greatest susceptible and for WL chickens to be the most resistant, but turkeys were susceptible to two LPAIV tested when used at moderate challenge doses. This suggests domestic ducks and geese, turkeys, and Japanese quail could serve as bridging species for LPAIVs from wild waterfowl to chickens and other gallinaceous poultry. These data do provide support for the commonly held and intuitive belief that mixing of poultry species during rearing and in outdoor production systems is a major risk factor for interspecies transmission of AIVs and for the emergence of new AIV strains capable of causing AI outbreaks because these situations present a more diverse host population to circumvent the natural host dependency or host range of circulating viruses.

Utilización de la dosis infecciosa media de virus de influenza aviar de alta o baja patogenicidad originados de aves domésticas o patos silvestres como una medida de infectividad y adaptación a las aves domésticas.

Las dosis infecciosas medias de aislamientos seleccionados del virus de influenza aviar determinadas bajo condiciones experimentales en aves domésticas, demostraron ser dependientes del huésped y de la cepa del virus, pudiendo considerarse como una medida de la infectividad y adaptación a un huésped específico. Como tal, las dosis infectivas medias podrían servir para predecir cuantitativamente cuáles cepas del virus de influenza aviar, dadas las condiciones adecuadas, sería más propensa a ser transmitida y mantenida en una especie determinada o subsecuentemente causar un brote de influenza aviar es esa especie. En aves leghorn blancas, se calculó la dosis infecciosa media 50 por ave (por sus siglas en Inglés BID50) de 11 aislamientos de influenza aviar de alta patogenicidad originados en pollos y pavos p

David E. Swayne and Richard D. Slemons "Using Mean Infectious Dose of High- and Low-Pathogenicity Avian Influenza Viruses Originating from Wild Duck and Poultry as One Measure of Infectivity and Adaptation to Poultry," Avian Diseases 52(3), 455-460, (1 September 2008). https://doi.org/10.1637/8229-012508-Reg.1
Received: 11 February 2008; Accepted: 1 April 2008; Published: 1 September 2008
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