Translator Disclaimer
1 March 2010 Protective Efficacy of the H5 Inactivated Vaccine Against Different Highly Pathogenic H5N1 Avian Influenza Viruses Isolated in China and Vietnam
Author Affiliations +
Abstract

An inactivated H5N1 avian influenza (AI) vaccine generated by reverse genetics and containing the hemagglutinin and neuraminidase genes of the H5N1 A/goose/Guangdong/1/96 (GS/GD/06) virus has been used in domestic poultry in China and Vietnam as an important control strategy for H5N1 AI. The efficacy of this vaccine against early H5N1 isolates has been fully evaluated in chicken, ducks, and geese. However, there are no reports about its efficacy against H5N1 viruses recently isolated in China and Vietnam. In this study, groups of 3-wk-old specific-pathogen-free chickens were intramuscularly injected with one dose of the vaccine. Three weeks postvaccination, the chickens were intranasally challenged with 105EID50 of six different lethal H5N1 AI viruses: A/bar-headed goose/Qinghai/3/05 (clade 2.2), A/chicken/Shanxi/2/06 (CK/SX/06; clade 7), A/duck/Fujian/31/07 (clade 2.3.4), A/MDK/VN-HD/46/07 (clade 2.3.4), A/MDK/VN-CM/1185/06 (clade 1), and A/MDK/VN-CM/1159/06 (clade 1). Four out of 20 chickens challenged with the CK/SX/06 shed virus on day 5 and died on day 8 to 9 postchallenge. Chickens challenged with the remaining five viruses were completely protected (no disease signs, virus shedding, or deaths). These results indicate that the GS/GD/06-based vaccine provides sound protection against clade 1, 2.2, and 2.3.4 viruses, but not against the CK/SX/06 virus, which emerged in northern China in 2006.

Guobin Tian, Xianying Zeng, Yanbing Li, Jianzhong Shi, and Hualan Chen "Protective Efficacy of the H5 Inactivated Vaccine Against Different Highly Pathogenic H5N1 Avian Influenza Viruses Isolated in China and Vietnam," Avian Diseases 54(s1), 287-289, (1 March 2010). https://doi.org/10.1637/8707-031709-ResNote.1
Received: 18 March 2009; Accepted: 1 July 2009; Published: 1 March 2010
JOURNAL ARTICLE
3 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top