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1 March 2012 Response of White Leghorn Chickens to Infection with Avian Leukosis Virus Subgroup J and Infectious Bursal Disease Virus
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Abstract

The effects of viral-induced immunosuppression on the infectious status (viremia and antibody) and shedding of avian leukosis virus (ALV) were studied. Experimental white leghorn chickens were inoculated with ALV subgroup J (ALV-J) and infectious bursal disease virus (IBDV) at day of hatch with the ALV-J ADOL prototype strain Hc1, the Lukert strain of IBDV, or both. Appropriate groups were exposed a second time with the Lukert strain at 2 wk of age. Serum samples were collected at 2 and 4 wk of age for IBDV antibody detection. Samples for ALV-J viremia, antibody detection, and cloacal shedding were collected at 4, 10, 18, and 30 wk of age. The experiment was terminated at 30 wk of age, and birds were necropsied and examined grossly for tumor development. Neoplasias detected included hemangiomas, bile duct carcinoma, and anaplastic sarcoma of the nerve. Control birds and IBDV-infected birds were negative for ALV-J–induced viremia, antibodies, and cloacal shedding throughout experiment. By 10 wk, ALV-J–infected groups began to develop antibodies to ALV-J. However, at 18 wk the incidence of virus isolation increased in both groups, with a simultaneous decrease in antibody levels. At 30 wk, 97% of birds in the ALV-J group were virus positive and 41% were antibody positive. In the ALV-J/IDBV group, 96% of the birds were virus positive at 30 wk, and 27% had antibodies to ALV-J. In this study, infection with a mild classic strain of IBDV did not influence ALV-J infection or antibody production.

American Association of Avian Pathologists
Susan M. Williams and Holly S. Sellers "Response of White Leghorn Chickens to Infection with Avian Leukosis Virus Subgroup J and Infectious Bursal Disease Virus," Avian Diseases 56(1), (1 March 2012). https://doi.org/10.1637/9577-101510-Reg.1
Received: 15 October 2010; Accepted: 1 February 2011; Published: 1 March 2012
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