Previous findings indicate that undirected singing performed by the male zebra finch (Taeniopygia guttata) is decreased following 2-deoxyglucose (2-DG) administration. 2-DG, a glucose analog that is not metabolized by mitochondria, is considered a metabolic stressor, causing a switch from carbohydrate to lipid metabolism, thus mimicking dietary restriction (DR). DR suppresses free radical production, thus reducing oxidative stress; reduced levels of oxidative stress are correlated with a decreased incidence of age-related disorders including cancers, diabetes and cardiovascular diseases. The present study examines the possibility of using 2-DG as a metabolic stressor in the zebra finch in order to study mechanisms of action in aging and age-related disorders. Morphology of mitochondria in liver and brain tissue and morphology of heart and liver tissue is studied. Physiological parameters, such as vocalization, body weight, food intake and corticosterone production are examined. Our results showed that 2-DG causes oncosis and a collapse of the outer membranes of liver and brain mitochondria and altered the morphological structure of the liver and heart. In addition, it was shown that corticosterone levels were significantly increased in 2-DG treated animals, while song production and food intake were significantly decreased compared to the control-treated group. The zebra finch model can be used to further study the processes of mitochondrial dysfunction/oxidative stress and might contribute to the elucidation of the underlying mechanism(s) of the processes of aging and age-related disorders.
You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither BioOne nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the BioOne website.
Vol. 79 • No. 3