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1 September 2008 Research Article: The effects of 2-deoxyglucose in the male zebra finch
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Previous findings indicate that undirected singing performed by the male zebra finch (Taeniopygia guttata) is decreased following 2-deoxyglucose (2-DG) administration. 2-DG, a glucose analog that is not metabolized by mitochondria, is considered a metabolic stressor, causing a switch from carbohydrate to lipid metabolism, thus mimicking dietary restriction (DR). DR suppresses free radical production, thus reducing oxidative stress; reduced levels of oxidative stress are correlated with a decreased incidence of age-related disorders including cancers, diabetes and cardiovascular diseases. The present study examines the possibility of using 2-DG as a metabolic stressor in the zebra finch in order to study mechanisms of action in aging and age-related disorders. Morphology of mitochondria in liver and brain tissue and morphology of heart and liver tissue is studied. Physiological parameters, such as vocalization, body weight, food intake and corticosterone production are examined. Our results showed that 2-DG causes oncosis and a collapse of the outer membranes of liver and brain mitochondria and altered the morphological structure of the liver and heart. In addition, it was shown that corticosterone levels were significantly increased in 2-DG treated animals, while song production and food intake were significantly decreased compared to the control-treated group. The zebra finch model can be used to further study the processes of mitochondrial dysfunction/oxidative stress and might contribute to the elucidation of the underlying mechanism(s) of the processes of aging and age-related disorders.

Wildaliz Nieves, Evan Johnson, Jason Patzwald, and Susanne L. T. Cappendijk "Research Article: The effects of 2-deoxyglucose in the male zebra finch," BIOS 79(3), 83-91, (1 September 2008).[83:TEODIT]2.0.CO;2
Accepted: 1 January 2008; Published: 1 September 2008

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