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1 February 2009 Biological Resource Centers and Systems Biology
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Abstract
There are hundreds of biological resource centers (BRCs) around the world, holding many little-studied microorganisms. The proportion of bacterial strains that is well represented in the sequence and literature databases may be as low as 1%. This body of unexplored diversity represents an untapped source of useful strains and derived products. However, a modicum of phenotypic data is available for almost all the bacterial strains held by BRCs around the world. It is at the phenotypic level that our knowledge of the well-studied strains of bacteria and the many yet to be studied strains intersect. Thus, we might leverage the phenotypic data from the data-poor bacteria with the omics data from the data-rich bacteria, using our knowledge of their evolutionary relationships, to map the metabolic networks of the little-known bacteria. This systems biology—based approach is a new way to explore the diversity harbored in BRCs.
© 2009 by American Institute of Biological Sciences. All rights reserved. Request permission to photocopy or reproduce article content at the University of California Press's Rights and Permissions Web site at www.ucpressjournals.com/reprintinfo.asp.
Yufeng Wang and Timothy G. Lilburn "Biological Resource Centers and Systems Biology," BioScience 59(2), (1 February 2009). https://doi.org/10.1525/bio.2009.59.2.5
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