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1 May 2001 Effect of Age and Breeding Season on the Developmental Capacity of Oocytes from Unstimulated and Follicle-Stimulating Hormone-Stimulated Rhesus Monkeys
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Abstract

Effects of age and season on the developmental capacity of oocytes from unstimulated and FSH-stimulated rhesus monkeys were examined. Immature cumulus-oocyte complexes were matured in vitro in modified CMRL-1066 medium containing 20% bovine calf serum and subjected to in vitro fertilization followed by embryo culture. After fertilization, ova from unstimulated prepubertal monkeys displayed lower development to morula (4%) than those from unstimulated adult females (18% in breeding season and 22% in nonbreeding season). No developmental difference was found between ova from unstimulated adult monkeys in breeding and nonbreeding seasons. However, ova from FSH-primed prepubertal monkeys displayed greater development to blastocyst stage (54%) than those from adult monkeys in the breeding season (16%) and nonbreeding season (0%); and ova from FSH-primed adult females in the breeding season had significantly (P < 0.05) greater developmental competence than those obtained in the nonbreeding season (≥morula stage, 54% vs. 3%; blastocyst stage, 16% vs. 0%). These data indicate that 1) rhesus monkey oocytes acquire developmental competence in a donor age-dependent manner, and 2) animal age and breeding season modulate the effect of FSH on oocyte developmental competence in the rhesus monkey.

P. Zheng, W. Si, H. Wang, R. Zou, B. D. Bavister, and W. Ji "Effect of Age and Breeding Season on the Developmental Capacity of Oocytes from Unstimulated and Follicle-Stimulating Hormone-Stimulated Rhesus Monkeys," Biology of Reproduction 64(5), 1417-1421, (1 May 2001). https://doi.org/10.1095/biolreprod64.5.1417
Received: 28 August 2000; Accepted: 1 December 2000; Published: 1 May 2001
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