Translator Disclaimer
1 August 2001 Testosterone Suppresses Spermatogenesis in Juvenile Spermatogonial Depletion (jsd ) Mice
Author Affiliations +
Abstract

Male juvenile spermatogonial depletion (jsd/jsd) mice are sterile because of a failure of spermatogonial differentiation. We have previously reported the recovery of spermatogonial differentiation by suppressing the levels of gonadotropins and testosterone with Nal-Glu, a GnRH antagonist. To determine whether suppression of testosterone or the gonadotropins was responsible for spermatogenic recovery, we examined the effect of supplementation of LH or FSH along with Nal-Glu treatment. Systemic administration of flutamide, an androgen receptor antagonist, was also examined. LH supplementation elevated both serum and intratesticular testosterone levels and suppressed the recovery of spermatogonial differentiation in a dose-dependent manner. Supplementation with FSH did not affect either testosterone levels or spermatogonial differentiation. Furthermore, the mice treated with flutamide showed some recovery of spermatogonial differentiation. The overall findings revealed that testosterone action mediated by androgen receptors suppressed the spermatogonial differentiation in jsd/jsd mice and suggested that spermatogonial differentiation in the jsd mutant is highly sensitive to testosterone suppression.

Akira Tohda, Kiyomi Matsumiya, Yuko Tadokoro, Kentaro Yomogida, Yasushi Miyagawa, Kayoko Dohmae, Akihiko Okuyama, and Yoshitake Nishimune "Testosterone Suppresses Spermatogenesis in Juvenile Spermatogonial Depletion (jsd ) Mice," Biology of Reproduction 65(2), 532-537, (1 August 2001). https://doi.org/10.1095/biolreprod65.2.532
Received: 22 January 2001; Accepted: 1 April 2001; Published: 1 August 2001
JOURNAL ARTICLE
6 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top