Translator Disclaimer
1 May 2002 Germ Line Stem Cell Competition in Postnatal Mouse Testes
Author Affiliations +
Abstract

Niche is believed to affect stem cell behavior. In self-renewing systems for which functional transplantation assays are available, it has long been assumed that stem cells are fixed in the niche and that ablative treatments to remove endogenous stem cells are required for successful donor engraftment. Our results demonstrate that enriched populations of donor stem cells can produce long-lasting spermatogenic colonies in testes of immature and mature, nonablated mice, albeit at a lower frequency than in ablated mice. Colonization of nonablated recipient testes by neonate, pup, and cryptorchid adult donor spermatogonial stem cells demonstrates that competition for niche begins soon after birth and that endogenous stem cells influence the degree and pattern of donor cell colonization. Thus, a dynamic relationship between stem cell and niche exists in the testis, as has been suggested for hematopoiesis. Therefore, similar competitive properties of donor stem cells may be characteristic of all self-renewing systems.

Takashi Shinohara, Kyle E. Orwig, Mary R. Avarbock, and Ralph L. Brinster "Germ Line Stem Cell Competition in Postnatal Mouse Testes," Biology of Reproduction 66(5), 1491-1497, (1 May 2002). https://doi.org/10.1095/biolreprod66.5.1491
Received: 1 November 2001; Accepted: 1 December 2001; Published: 1 May 2002
JOURNAL ARTICLE
7 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top