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1 October 2002 Viewpoint on the Functionality of the Human Leukocyte Antigen-G Null Allele at the Fetal-Maternal Interface
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Abstract

The description of healthy individuals homozygous for the human leukocyte antigen-G (HLA-G) null allele raised doubts about the role of HLA-G in fetal-maternal tolerance. In light of recent results, we discuss this point by considering the potential activity of this null allele that might, indeed, produce functional truncated HLA-G molecules. In this context, we have recently described that, like the full-length HLA-G1, the HLA-G2, -G3, and -G4 truncated isoforms may be expressed at the cell surface and may modulate both innate and acquired immune responses.

Philippe Moreau, Jean Dausset, Edgardo D. Carosella, and Nathalie Rouas-Freiss "Viewpoint on the Functionality of the Human Leukocyte Antigen-G Null Allele at the Fetal-Maternal Interface," Biology of Reproduction 67(5), 1375-1378, (1 October 2002). https://doi.org/10.1095/biolreprod.102.005439
Received: 12 March 2002; Accepted: 1 June 2002; Published: 1 October 2002
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