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1 January 2003 Mitochondrial DNA Content of Human Spermatozoa
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Abstract

Sperm mitochondria play an important role in spermatozoa because of the high ATP demand of these cells. Different mitochondrial DNA (mtDNA) mutations and haplogroups influence sperm function. The mtDNA dose also contributes to genetic variability and pathology in different tissues and organs, but nothing is known about its relevance in the performance of spermatozoa. We estimated the variability in mtDNA content within a population of men. Different mtDNA:nuclear DNA ratios were characteristic of progressive and nonprogressive spermatozoa, confirming the influence of mtDNA content on sperm functionality. We also estimated that the absolute content of mtDNA was 700 and 1200 mtDNA copies per cell in progressive and nonprogressive human spermatozoa, respectively. These results suggest that a marked increase of mtDNA copy number per cell volume takes place during spermatogenesis.

Carmen Díez-Sánchez, Eduardo Ruiz-Pesini, Ana Cristina Lapeña, Julio Montoya, Acisclo Pérez-Martos, José Antonio Enríquez, and Manuel J. López-Pérez "Mitochondrial DNA Content of Human Spermatozoa," Biology of Reproduction 68(1), 180-185, (1 January 2003). https://doi.org/10.1095/biolreprod.102.005140
Received: 5 March 2002; Accepted: 1 July 2002; Published: 1 January 2003
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