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1 February 2003 Changes in the Expression of Tumor Necrosis Factor (TNF) α, TNFα Receptor (TNFR) 2, and TNFR-Associated Factor 2 in Granulosa Cells During Atresia in Pig Ovaries
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Abstract

Tumor necrosis factor (TNF) α can induce both cell death and cell proliferation and exerts its effects by binding to either TNF receptor (TNFR) 1 or 2. When TNFα-bound TNFR2 interacts with TNFR-associated factor 2 (TRAF2), expression of survival/antiapoptotic genes is up-regulated. In the present study we determined the changes in localization of TNFα and TRAF2 and their mRNAs and the expression of TNFR2 in granulosa cells during follicular atresia in pig ovaries. In healthy follicles, intense signals for TNFα and TRAF2 and their mRNAs were demonstrated in the outer zone of the granulosa layer, where many proliferating cells and no apoptotic cells were observed. In atretic follicles, decreased or trace staining for TRAF2 and its mRNA and decreased expression of TNFR2 were observed in the granulosa layer, where many apoptotic cells were seen. These findings suggested that TNFα acts as a survival factor in granulosa cells during follicular atresia in pig ovaries.

Mizuho Nakayama, Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, and Hajime Miyamoto "Changes in the Expression of Tumor Necrosis Factor (TNF) α, TNFα Receptor (TNFR) 2, and TNFR-Associated Factor 2 in Granulosa Cells During Atresia in Pig Ovaries," Biology of Reproduction 68(2), 530-535, (1 February 2003). https://doi.org/10.1095/biolreprod.102.004820
Received: 20 February 2002; Accepted: 1 August 2002; Published: 1 February 2003
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