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1 October 2003 Amino Acid Transport Regulates Blastocyst Implantation
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Abstract

Mouse blastocyst outgrowth in vitro and probably implantation in vivo require amino acid signaling via the target of rapamycin (TOR) pathway. This signaling does not simply support protein synthesis and trophoblast differentiation. Rather, it regulates development of trophoblast protrusive activity and may act as a developmental checkpoint for implantation. Moreover, intracellular amino acids per se are insufficient to elicit TOR signaling. Instead, de novo transport of amino acids, and particularly of leucine, stimulate mTOR activity at the blastocyst stage. The activity of the broad-scope and yet leucine-selective amino acid transport system B0, could produce such increases in intracellular amino acid concentrations. For example, system B0, uses a Na gradient to drive amino acid uptake, and the Na concentration in uterine secretions increases by nearly two-fold about 18 h before implantation. The resultant mTOR signaling could trigger polyamine, insulin-like growth factor II, and nitric oxide production in blastocysts and the increased cell motility sometimes associated with synthesis of these bioactive molecules.

Patrick M. Martin, Ann E. Sutherland, and Lon J. Van Winkle "Amino Acid Transport Regulates Blastocyst Implantation," Biology of Reproduction 69(4), 1101-1108, (1 October 2003). https://doi.org/10.1095/biolreprod.103.018010
Received: 9 April 2003; Accepted: 1 May 2003; Published: 1 October 2003
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