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1 April 2004 Developmental Distribution of the Polyadenylation Protein CstF-64 and the Variant τCstF-64 in Mouse and Rat Testis
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Abstract

Messenger RNA polyadenylation is one of the processes that control gene expression in all eukaryotic cells and tissues. In mice, two forms of the regulatory polyadenylation protein CstF-64 are found. The gene Cstf2 on the X chromosome encodes this form, and it is expressed in all somatic tissues. The second form, τCstF-64 (encoded by the autosomal gene Cstf2t), is expressed in a more limited set of tissues and cell types, largely in meiotic and postmeiotic male germ cells and, to a smaller extent, in brain. We report here that whereas CstF-64 and τCstF-64 expression in rat tissues resembles their expression in mouse tissues, significant differences also are found. First, unlike in mice, in which CstF-64 was expressed in postmeiotic round and elongating spermatids, rat CstF-64 was absent in those cell types. Second, unlike in mice, τCstF-64 was expressed at significant levels in rat liver. These differences in expression suggest interesting differences in X-chromosomal gene expression between these two rodent species.

A. Michelle Wallace, Toni L. Denison, Ebtesam N. Attaya, and Clinton C. MacDonald "Developmental Distribution of the Polyadenylation Protein CstF-64 and the Variant τCstF-64 in Mouse and Rat Testis," Biology of Reproduction 70(4), 1080-1087, (1 April 2004). https://doi.org/10.1095/biolreprod.103.022947
Received: 4 September 2003; Accepted: 1 December 2003; Published: 1 April 2004
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