Translator Disclaimer
1 June 2004 Telomere Lengths in Cloned Transgenic Pigs
Author Affiliations +
Abstract

Studies of cloned cattle and mice have resulted in controversies regarding the restoration of eroded telomere length of donor cells by the nuclear transfer process. Little is known about telomere lengths in pigs from either natural reproduction or nuclear transfer. In this study, we measured the telomere lengths in six major porcine organs from animals of different ages, and found that their lengths remained consistent throughout different tissues during fetal stages, and then shortened, in a tissue- specific manner, after birth. Telomeres of skin samples from six cloned transgenic pigs at 4 mo of age did not differ significantly from those of age-matched controls. Two cloned pigs that died shortly after birth had skin telomere lengths equivalent to those of late-stage fetuses.

Le Jiang, D. Bart Carter, Jie Xu, Xiangzhong Yang, Randall S. Prather, and X. Cindy Tian "Telomere Lengths in Cloned Transgenic Pigs," Biology of Reproduction 70(6), 1589-1593, (1 June 2004). https://doi.org/10.1095/biolreprod.103.022616
Received: 25 August 2003; Accepted: 22 January 2004; Published: 1 June 2004
JOURNAL ARTICLE
5 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top