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1 May 2005 Fra1 Activity in the Frog, Rana esculenta, Testis: A New Potential Role in Sperm Transport
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Abstract

Using an anti-Fos family member antibody, we have previously described in Rana esculenta testis the presence of a nuclear, 43 kDa protein that we hypothesized to be Fra1. With the assistance of an antibody against Fra1 that does not cross-react with other Fos family members, here we report data on Fra1 expression, localization, and putative activity in Rana esculenta testis during its annual reproductive cycle. Western blot analysis confirms that the nuclear, 43 kDa protein is Fra1. Immunocytochemistry validates the Western blot results and shows cytoplasmic and nuclear immunostaining of Fra1 in peritubular myoid cells, efferent ducts, and blood vessels. We report for the first time in a vertebrate, experimental evidence showing that the expression of Fra1 is related to peritubular myoid cells during sperm transport from the tubular compartment to efferent ducts.

Gilda Cobellis, Monica Lombardi, Donatella Scarpa, Gaia Izzo, Giulia Fienga, Rosaria Meccariello, Riccardo Pierantoni, and Silvia Fasano "Fra1 Activity in the Frog, Rana esculenta, Testis: A New Potential Role in Sperm Transport," Biology of Reproduction 72(5), 1101-1108, (1 May 2005). https://doi.org/10.1095/biolreprod.104.036541
Received: 27 September 2004; Accepted: 1 December 2004; Published: 1 May 2005
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