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1 June 2009 Antiproliferative Effects of Adiponectin on Human Trophoblastic Cell Lines JEG-3 and BeWo
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Abstract

During embryo implantation, a complex dialog exists between the mother and the fetus. However, little is known about the molecules that participate in this process. Among various factors secreted at the maternal-fetal interface, the adipose tissue-derived leptin is now considered a placental growth factor. Adiponectin is another adipocyte-derived signaling molecule known to exert antiproliferative effects in various cell types. In this work, we studied adiponectin sensitivity and effects on JEG-3 and BeWo choriocarcinoma cell lines. First, we showed that JEG-3 and BeWo cells express the specific adiponectin receptors ADIPOR1 and ADIPOR2 and respond to human recombinant adiponectin by AMP-activated protein kinase (PRKA, also known as AMPK) activation. Second, we demonstrated that adiponectin induces a reduction in cell number and in [3H]-thymidine incorporation, demonstrating that adiponectin has antiproliferative effects on trophoblastic cells. Furthermore, these effects of adiponectin seem to be, at least in part, mediated by the mitogen-activated protein kinase (MAPK) and phosphoinositide-3-kinase (PI3K) signaling pathways. We describe herein the direct effects of adiponectin in the control of trophoblastic cell proliferation.

Delphine Benaitreau, Marie-Noëllé Dieudonné, Esther Dos Santos, Marie-Christine Leneveu, Philippede Mazancourt, and René Pecquery "Antiproliferative Effects of Adiponectin on Human Trophoblastic Cell Lines JEG-3 and BeWo," Biology of Reproduction 80(6), 1107-1114, (1 June 2009). https://doi.org/10.1095/biolreprod.108.070573
Received: 14 May 2008; Accepted: 1 January 2009; Published: 1 June 2009
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