Translator Disclaimer
10 June 2009 A Novel, Single, Transmembrane Protein CATSPERG Is Associated with CATSPER1 Channel Protein
Author Affiliations +
Abstract

All four CATSPER channel pore-forming subunits (CATSPER1–4) are localized in the sperm principal piece. They form an alkalization-activated Ca2 -permeable channel and are required for sperm-hyperactivated motility, egg coat penetration, and male fertility. Unlike many other ion channels, the composition of the CATSPER protein complex is poorly defined. Herein, we describe the novel protein CATSPERG associated with the CATSPER complex. CATSPERG is predicted to be a single transmembrane-spanning protein with a large extracellular domain and a short intracellular tail. Like all the CATSPERs and the previously identified CATSPER-associated protein CATSPERB, CATSPERG is only expressed in testis and is localized in the sperm principal piece. In CATSPER1-deficient sperm, the CATSPERG protein (but not the K channel protein KCNU1) is also lost. Together with previous findings, our data suggest that the CATSPER protein complex contains pore-forming proteins and two additional proteins (CATSPERB and CATSPERG) and that the trafficking and/or assembly of these proteins depends on CATSPER1.

Haikun Wang, Jin Liu, Kwang-Hyun Cho, and Dejian Ren "A Novel, Single, Transmembrane Protein CATSPERG Is Associated with CATSPER1 Channel Protein," Biology of Reproduction 81(3), 539-544, (10 June 2009). https://doi.org/10.1095/biolreprod.109.077107
Received: 25 February 2009; Accepted: 1 May 2009; Published: 10 June 2009
JOURNAL ARTICLE
6 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top