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25 August 2010 Transformation-Related Protein 53 Expression in the Early Mouse Embryo Compromises Preimplantation Embryonic Development by Preventing the Formation of a Proliferating Inner Cell Mass
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Abstract

The developmental viability of the preimplantation embryo requires the successful formation of a cluster of pluripotent stem cells called the inner cell mass. Development is variably compromised by a range of exogenous stressors (including their production by assisted reproductive technologies). Inbred C57BL/6 strain embryos are particularly susceptible to the stresses associated with embryo culture, whereas hybrid embryos are more resistant, and this is accounted for in part by the overexpression of transformation-related protein 53 in cultured inbred embryos compared with similarly treated hybrid embryos or embryos not subjected to culture. We show here that this loss of viability is a consequence of the Trp53-dependent reduction in the capacity of blastocysts to form a proliferating inner cell mass. Formation of the trophectodermal line was not adversely affected by these stresses.

Lakshi Ganeshan, Aiqing Li, and Chris O'Neill "Transformation-Related Protein 53 Expression in the Early Mouse Embryo Compromises Preimplantation Embryonic Development by Preventing the Formation of a Proliferating Inner Cell Mass," Biology of Reproduction 83(6), 958-964, (25 August 2010). https://doi.org/10.1095/biolreprod.109.083162
Received: 17 December 2009; Accepted: 1 August 2010; Published: 25 August 2010
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