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11 November 2015 The Role of Retinoic Acid (RA) in Spermatogonial Differentiation
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Abstract

Retinoic acid (RA) directs the sequential, but distinct, programs of spermatogonial differentiation and meiotic differentiation that are both essential for the generation of functional spermatozoa. These processes are functionally and temporally decoupled, as they occur in distinct cell types that arise over a week apart, both in the neonatal and adult testis. However, our understanding is limited in terms of what cellular and molecular changes occur downstream of RA exposure that prepare differentiating spermatogonia for meiotic initiation. In this review, we describe the process of spermatogonial differentiation and summarize the current state of knowledge regarding RA signaling in spermatogonia.

© 2016 by the Society for the Study of Reproduction, Inc.
Jonathan T. Busada and Christopher B. Geyer "The Role of Retinoic Acid (RA) in Spermatogonial Differentiation," Biology of Reproduction 94(1), (11 November 2015). https://doi.org/10.1095/biolreprod.115.135145
Received: 1 September 2015; Accepted: 1 November 2015; Published: 11 November 2015
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