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1 June 2012 Short Communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats
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Abstract

Manunza, A., Zidi, A., Fernández-Cabanás, V. M., Jordana, J., Carrizosa, J., Belaifa, E., Urrutia, B., Polvillo, O., González-Redondo, P., Amills, M. and Serradilla, J. M. 2012. Short Communication: An association analysis between one missense polymorphism at theSREBF1gene and milk yield and composition traits in goats. Can. J. Anim. Sci. 92: 167-173. Sterol regulatory element binding transcription factor 1 (SREBF1) regulates the expression of genes involved in the biosynthesis of fatty acids and cholesterol. Herewith, we have sequenced the near-complete coding region and part of the 3'UTR of the goat SREBF1 gene. In doing so, we have detected a missense c.353C>T polymorphism causing a proline to leucine substitution at position 118 (P118L). An association analysis with milk composition traits recorded in Murciano-Granadina goats only revealed a statistical tendency linking SREBF1 genotype and milk omega-3 fatty acid content. The lack of significant associations suggests that the P118L substitution does not involve a functional change.

A. Manunza, A. Zidi, V. M. Fernández-Cabanás, J. Jordana, J. Carrizosa, E. Belaifa, B. Urrutia, O. Polvillo, P. González-Redondo, M. Amills, and J. M. Serradilla "Short Communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats," Canadian Journal of Animal Science 92(2), 167-173, (1 June 2012). https://doi.org/10.1139/CJAS2011-111
Received: 7 October 2011; Accepted: 7 February 2012; Published: 1 June 2012
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