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16 October 2018 The cholesterol-deficiency associated mutation in APOB segregates at low frequency in Chinese Holstein cattle
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Abstract

Cholesterol deficiency (CD) is a recessive genetic defect in Holstein cattle, which affects the rearing success of calves. We investigated whether CD has been spread into the People’s Republic of China. A total of 138 Holstein bulls and 90 cows were screened for CD using polymerase chain reaction amplification and then seven bulls (5.07%) and one cow (1.11%) were identified as CD carriers. Pedigree analyses revealed that all seven CD carrier bulls were traced back to MAUGHLIN STORM and CD may have spread into the People’s Republic of China through his daughter, Braedale Baler Twine. Our results demonstrated that the CD defect exists in the Chinese Holstein population.

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Yanhua Li, Lingzhao Fang, Lin Liu, Shengli Zhang, Zhu Ma, and Dongxiao Sun "The cholesterol-deficiency associated mutation in APOB segregates at low frequency in Chinese Holstein cattle," Canadian Journal of Animal Science 99(2), 332-335, (16 October 2018). https://doi.org/10.1139/cjas-2017-0108
Received: 25 July 2017; Accepted: 4 September 2018; Published: 16 October 2018
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