This paper evaluates the bioavailability of allium derivative propyl propane thiosulfonate (PTSO) in the pig gastrointestinal tract by means of an in vitro dynamic gastrointestinal tract simulator system (GITSS). The GITSS is based on a membrane bioreactor comprising a continuous stirred-tank reactor connected in series to a continuous plug-flow tubular reactor. Bioavailability values have been evaluated for different vehiculization strategies, including mere carriers such as polyethylene glycol sorbitan monooleate (a nonionic surfactant also known as Tween 80) and encapsulation matrices (β-cyclodextrin vs. mono- and di-glycerides of edible fatty acids mixed with hydrogenated sunflower oil) and compared with the absorption of free PTSO. The net absorbed amount of PTSO in the GITSS when Tween 80 was used as a carrier was over 3.5 times higher than the one for free PTSO. Neither the encapsulated PTSO in β-cyclodextrin nor by means of mono- and di-glycerides of fatty acids plus a vegetable oil succeeded to improve absorption values for free PTSO. These promising results indicate that Tween 80 provides an interesting and high resistance to the PTSO molecule against the simulated digestive conditions in the stomach, and thus it enables favorably the subsequent absorption process of PTSO along the intestine.
You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither BioOne nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the BioOne website.
Vol. 99 • No. 2