Mangrove wetlands are being altered by human impacts throughout the Caribbean and Bahamas at an alarming rate. There is a pressing need for a set of criteria that can be used to identify the degree of anthropogenic impact, as well as to identify those areas most suitable for conservation and/or restoration initiatives. We provide a set of taxa that can be used as indicators in mangrove-dominated tidal creek ecosystems. The analysis was based on gradients of human impact measured at both local (tidal creek fragmentation) and regional (human threat indices) spatial scales. Such indicator taxa provide a simple tool for local resource managers, policy makers, and educators, and can be used for rapid assessments of human impacts on floral and faunal assemblages in tidal creeks.