Homeomorpha mackiewiczi n. gen. n. sp. is described from spotted suckers, Minytrema melanops, collected from a small stream in the Big Thicket National Preserve, Texas, U.S.A. The new genus is a member of the Caryophyllaeidae and is characterized by a uterus that loops anteriorly to the cirrus sac by more than the width of the uterus, preovarian vitelline follicles in distinct lateral rows, H-shaped ovary, 2 gonopores with genital atrium, an external seminal vesicle, postovarian vitellaria, and a cuneiloculate scolex. The new genus most closely resembles Hypocaryophyllaeus and Glaridacris, but members of Hypocaryophyllaeus do not possess postovarian vitellaria and members of Glaridacris have a uterus that does not loop anteriorly of the cirrus sac.