The Nearctic genus Coquillettia Uhler is revised and moved to the tribe Phylini; 14 new species are described for a total of 29 valid species. The following six new synonyms are proposed (senior synonym first): Coquillettia albiclava Knight = C. aquila Bliven and C. saxetana Bliven, C. foxi Van Duzee = C. terrosa Bliven, C. insignis Uhler = C. numata Bliven and C. uhleri Van Duzee, and C. mimetica Osborn = C. mimetica floridana Knight. Coquillettia amoenus (Uhler) is treated as a nomen dubium. A lectotype is designated for C. mimetica Osborn. The 14 new species described within Coquillettia are: concava, gigantea, impluviata, lactea, obscura, pergrandis, perplexabilis, polhemorum, pseudoattica, schuhi, schwartzi, thomasi, venusta, and vicina.Two new genera, Leutiola and Ticua, are described within the Phylini to accommodate species previously placed in Coquillettia. Coquillettia ajo Knight is transferred to Leutiola where C. virescens Knight is proposed as a junior synonym of L. ajo. Two new species are described within Leutiola: L. mapa and L. mexicana. Coquillettia granulata Knight is transferred to Ticua. Coquillettia laticeps is proposed as stat. nov.Diagnoses, descriptions, color digital habitus photographs, and illustrations of male genitalia are provided for all species. Female genitalic illustrations are included for selected species of each genus. Scanning micrographs of selected structures are presented to document diagnostic characters of the genera. Maps and label data are integrated to portray the distributions of all included species. Keys are presented for the genera and males of all species.