Fifty-four taxa of calicioid lichens and fungi are reported for Great Smoky Mountains National Park. Short narratives provide information on substrate(s), distribution within the park, and up to four representative specimens for each species. As a group of species that prefer older, undisturbed forests and clean air, the calicioid lichens are finding neither. The structural integrity of the forests has been ravaged by insect and fungal attack and air pollution has been a problem for far too long. The poor health of these species raises concern for the health of the park's ecosystems.