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1 October 2004 EFFECTS OF GENETIC DRIFT ON VARIANCE COMPONENTS UNDER A GENERAL MODEL OF EPISTASIS
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Abstract

We analyze the changes in the mean and variance components of a quantitative trait caused by changes in allele frequencies, concentrating on the effects of genetic drift. We use a general representation of epistasis and dominance that allows an arbitrary relation between genotype and phenotype for any number of diallelic loci. We assume initial and final Hardy-Weinberg and linkage equilibrium in our analyses of drift-induced changes. Random drift generates transient linkage disequilibria that cause correlations between allele frequency fluctuations at different loci. However, we show that these have negligible effects, at least for interactions among small numbers of loci. Our analyses are based on diffusion approximations that summarize the effects of drift in terms of F, the inbreeding coefficient, interpreted as the expected proportional decrease in heterozygosity at each locus. For haploids, the variance of the trait mean after a population bottleneck is var(Δ) = Σnk=1 FkVA(k), where n is the number of loci contributing to the trait variance, VA(1) = VA is the additive genetic variance, and VA(k) is the kth-order additive epistatic variance. The expected additive genetic variance after the bottleneck, denoted ⟨V*A⟩, is closely related to var(Δ); ⟨V*A⟩ = (1 − F) Σnk=1 kFk−1VA(k). Thus, epistasis inflates the expected additive variance above VA(1 − F), the expectation under additivity. For haploids (and diploids without dominance), the expected value of every variance component is inflated by the existence of higher order interactions (e.g., third-order epistasis inflates ⟨V*AA⟩). This is not true in general with diploidy, because dominance alone can reduce ⟨V*A⟩ below VA(1 − F) (e.g., when dominant alleles are rare). Without dominance, diploidy produces simple expressions: var(Δ) = Σnk=1 (2F)kVA(k) and ⟨V*A⟩ = (1 − F) Σnk=1 k(2F)k−1VA(k). With dominance (and even without epistasis), var(Δ) and ⟨V*A⟩ no longer depend solely on the variance components in the base population. For small F, the expected additive variance simplifies to ⟨V*A⟩ ≃ (1 − F)VA 4FVAA 2FVD 2FCAD, where CAD is a sum of two terms describing covariances between additive effects and dominance and additive × dominance interactions. Whether population bottlenecks lead to expected increases in additive variance depends primarily on the ratio of nonadditive to additive genetic variance in the base population, but dominance precludes simple predictions based solely on variance components. We illustrate these results using a model in which genotypic values are drawn at random

N. H. Barton and Michael Turelli "EFFECTS OF GENETIC DRIFT ON VARIANCE COMPONENTS UNDER A GENERAL MODEL OF EPISTASIS," Evolution 58(10), 2111-2132, (1 October 2004). https://doi.org/10.1554/03-684
Received: 27 November 2003; Accepted: 15 June 2004; Published: 1 October 2004
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