Three new species Orphilus kabakovi sp. nov., Orphinus (s. str.) kabakovi sp. nov., Ctesias (Decemctesias) mroczkowskii sp. nov. (Coleoptera: Demestidae) are described from Afghanistan. The habitus, antenna, genitalia are illustrated and compared with related species. The species Attagenus indicus Kalík, 1954 and Anthrenus (Anthrenodes) amoenulus Reitter, 1896 are newly recorded from Afghanistan. Morphological details with dorsal variability of Attagenus indicus Kalík, 1954 are illustrated for the first time. A revised list of the species from Afghanistan is given.