Translator Disclaimer
1 December 2007 Effect of Apolipoprotein E Genotype and Saturated Fat Intake on Plasma Lipids and Myocardial Infarction in the Central Valley of Costa Rica
Author Affiliations +
Abstract

We assessed the effect of APOE polymorphisms –491 A/T, C112R (APOE*4), and R158C (APOE*2) and saturated fat intake on plasma lipid levels and risk of myocardial infarction (MI) in 1,927 case subjects and 1,927 population-based control subjects matched for age, sex, and residence, all living in the Central Valley of Costa Rica. A significant gene-diet interaction (p = 0.0157) was observed. High saturated fat intake was associated with a 49% increased risk of MI (OR = 1.49; 95% CI, 1.16–1.92) among wild-type subjects. In contrast, high saturated fat intake was associated with a 2.2-fold increased risk of MI among carriers of APOE*2 (OR = 3.17; 95% CI, 1.58–6.36) and with a 1.6-fold increase among carriers of the –491T and APOE*4 variants together (OR = 2.59; 95% CI, 1.38–4.87). Consistently, a high fat diet elicited a greater response in LDL cholesterol among carriers of APOE*2 ( 17%) and APOE*4 ( 14%) compared to noncarriers ( 6%). The frequency of APOE variants was similar in case and control subjects, although APOE*4 homozygotes were at increased risk of MI compared to noncarriers (OR = 2.26; 95% CI, 1.03–4.98). This study supports the hypothesis that the APOE*2 and APOE*4 variants increase susceptibility to MI in the presence of high saturated fat and could explain inconsistent findings on the effects of these variants on MI in various populations.

Yadong Yang, Edward Ruiz-Narvaez, Peter Kraft, and Hannia Campos "Effect of Apolipoprotein E Genotype and Saturated Fat Intake on Plasma Lipids and Myocardial Infarction in the Central Valley of Costa Rica," Human Biology 79(6), 637-647, (1 December 2007). https://doi.org/10.1353/hub.2008.0010
Received: 25 July 2005; Accepted: 1 January 2007; Published: 1 December 2007
JOURNAL ARTICLE
11 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top