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1 March 2003 TRANSFORMING GROWTH FACTOR–β1 ENHANCES THE SECRETION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 BY THE IEC-18 INTESTINAL EPITHELIAL CELL LINE
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Abstract

Intestinal epithelial cells (IEC) are known to produce monocyte chemoattractant protein–1 (MCP-1). However, MCP-1 production, as with many other cytokines, can be regulated by a network of cytokines present in the environment of the IEC. Both IEC and inflammatory cells have been shown to produce transforming growth factor–β (TGF-β), and the regulatory effect of this cytokine on MCP-1 secretion by IEC has not been determined. Using the IEC-18 cell line, we have found that TGF-β1 alone induced the secretion of high levels of MCP-1. Treatment with TGF-β1 also enhanced the levels of MCP-1 messenger ribonucleic acid. However, costimulation of the cells with TGF-β1 and interleukin-1β (IL-1β) resulted in significant, but less than additive, increases in MCP-1 secretion. Finally, the enhancing effect of TGF-β1 on MCP-1 secretion was not due to IL-6. These results suggest that TGF-β1 from IEC or inflammatory cells may significantly enhance the secretion of MCP-1 by IEC and play an important role in inflamed mucosal tissues.

LISA B. MATAGRANO, JASON A. MAGIDA, and DENNIS W. McGEE "TRANSFORMING GROWTH FACTOR–β1 ENHANCES THE SECRETION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 BY THE IEC-18 INTESTINAL EPITHELIAL CELL LINE," In Vitro Cellular & Developmental Biology - Animal 39(3), 183-186, (1 March 2003). https://doi.org/10.1290/1543-706X(2003)039<0183:TGFETS>2.0.CO;2
Received: 8 May 2003; Accepted: 24 June 2003; Published: 1 March 2003
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