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1 September 2003 PHENOTYPIC CHARACTERIZATION OF A HUMAN SYNOVIAL SARCOMA CELL LINE, SW982, AND ITS RESPONSE TO DEXAMETHASONE
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Abstract

SW982 cells are characterized by expression of inflammatory cytokine and matrix metalloproteinase (MMP) genes and by their response to dexamethasone at different cell densities. They express genes encoding interleukin (IL)-1β; IL-6; transforming growth factor–β; intercellular adhesion molecule–1; cycloxygenase (COX)-2; and MMPs, including MMP-1, MMP-2, MMP-13, and MT1-MMP; tissue inhibitor of metalloproteinase–2; and a disintegrin and metalloproteinase with thrombospondin motifs–4. Expression of all the genes examined was induced with 2 ng/ml IL-1β at low cell density. The cells, however, failed to express tumor necrosis factor–α, COX-1, and MMP-9, regardless of the presence of IL-1β. Dexamethasone significantly reduced IL-1β, IL-6, COX-2, and MMP-1 expression at high cell density. The results suggest that SW982 cells are a useful tool for studying the expression of inflammatory cytokine or MMP genes.

TAISUKE YAMAZAKI, TAKASHI YOKOYAMA, HIROMI AKATSU, TAKASHI TUKIYAMA, and TAKAYOSHI TOKIWA "PHENOTYPIC CHARACTERIZATION OF A HUMAN SYNOVIAL SARCOMA CELL LINE, SW982, AND ITS RESPONSE TO DEXAMETHASONE," In Vitro Cellular & Developmental Biology - Animal 39(8), 337-339, (1 September 2003). https://doi.org/10.1290/1543-706X(2003)039<0337:PCOAHS>2.0.CO;2
Received: 15 October 2003; Accepted: 20 November 2003; Published: 1 September 2003
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