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1 September 2003 STATIC MAGNETIC FIELD WITH A STRONG MAGNETIC FIELD GRADIENT (41.7 T/m) INDUCES C-JUN EXPRESSION IN HL-60 CELLS
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Abstract

We investigated the effects of 6- and 10-T static magnetic fields (SMFs) on the expression of protooncogenes using Western blot immunohybridization methods. We used a SMF exposure system, which can expose cells to a spatially inhomogeneous 6 T with a strong magnetic field (MF) gradient (41.7 T/m) and a spatially homogeneous 10 T of the highest magnetic flux density in this experiment. HL-60 cells exposed to either 6- or 10-T SMF for periods of 1 to 48 h did not exhibit remarkable differences in levels of c-Myc and c-Fos protein expression, as compared with sham-exposed cells. In contrast, c-Jun protein expression increased in HL-60 cells after exposure to 6-T SMF for 24, 36, 48, and 72 h. These results suggest that a homogeneous 10-T SMF does not alter the expression of the c-jun, c-fos, and c-myc protooncogenes. However, our observation that exposure to a strong MF gradient induced c-Jun expression suggests that a strong MF gradient may have significant biological effects, particularly regarding processes related to an elevation of c-jun gene expression.

HIDEKI HIROSE, TAKEHISA NAKAHARA, QIU-MEI ZHANG, SHUJI YONEI, and JUNJI MIYAKOSHI "STATIC MAGNETIC FIELD WITH A STRONG MAGNETIC FIELD GRADIENT (41.7 T/m) INDUCES C-JUN EXPRESSION IN HL-60 CELLS," In Vitro Cellular & Developmental Biology - Animal 39(8), 348-352, (1 September 2003). https://doi.org/10.1290/1543-706X(2003)039<0348:SMFWAS>2.0.CO;2
Received: 17 July 2003; Accepted: 22 September 2003; Published: 1 September 2003
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