Translator Disclaimer
1 March 2004 SUPPRESSIVE EFFECTS OF ASCORBATE DERIVATIVES ON ULTRAVIOLET-B–INDUCED INJURY IN HACAT HUMAN KERATINOCYTES
Author Affiliations +
Abstract

The aging of skin, including sunburning, is caused by ultraviolet (UV) irradiation. Here, we examined the inhibitory effect of ascorbic acid (AsA) and its derivatives AsA 2-phosphate (AA-2P) and AsA 2-glucoside (AA-2G) on UV-B– induced cytotoxicity in HaCaT keratinocytes. Results show that cell viability significantly decreased when exposed to UV-B at 0.1–0.4 J/cm2 in a dose-dependent manner. In this study, AsA could not inhibit cytotoxicity, but AA-2P and AA-2G was able to cancel the harmful effect of UV-B when treated at high levels of 0.5–5 mM. These results indicate that the masking of the C-2 OH group may be an effective modification for AsA to inhibit UV-B–induced cytotoxicity in human keratinocytes.

SHIN YASUDA, MIKIRO TADA, KOJI YAMADA, and KYOYA TAKAHATA "SUPPRESSIVE EFFECTS OF ASCORBATE DERIVATIVES ON ULTRAVIOLET-B–INDUCED INJURY IN HACAT HUMAN KERATINOCYTES," In Vitro Cellular & Developmental Biology - Animal 40(3), 71-73, (1 March 2004). https://doi.org/10.1290/1543-706X(2004)040<0071:SEOADO>2.0.CO;2
Received: 20 February 2004; Accepted: 9 April 2004; Published: 1 March 2004
JOURNAL ARTICLE
3 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top