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1 May 2005 MICROVASCULAR ENDOTHELIAL CELLS SUSTAIN PREADIPOCYTE VIABILITY UNDER HYPOXIC CONDITIONS
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Abstract

Obesity, soft tissue wound healing, adipose tissue engineering, lipomas, and other physiological and pathophysiological conditions necessitate a clear understanding of the interactions between adipocytes and endothelial cells. Adipogenesis and angiogenesis are intimately integrated, despite not being in direct apposition with one another. However, underlying mechanisms have not been elucidated. In this study, the interactions of preadipocytes (PAs) and microvascular endothelial cells are investigated under varying defined O2 conditions, using a coculture system. Results clearly demonstrate that endothelial cells release a soluble factor that sustains PAs viability under hypoxic conditions. Vascular endothelial cell growth factor is not the potential soluble factor (data not shown).

CYNTHIA A. FRYE, XUEMEI WU, and CHARLES W. PATRICK "MICROVASCULAR ENDOTHELIAL CELLS SUSTAIN PREADIPOCYTE VIABILITY UNDER HYPOXIC CONDITIONS," In Vitro Cellular & Developmental Biology - Animal 41(5), (1 May 2005). https://doi.org/10.1290/0502015.1
Received: 18 February 2005; Accepted: 11 April 2005; Published: 1 May 2005
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